Abstract
Tris-aromatic furanones (1-4) and related bis-aromatic diesters (5 and 6) isolated from the dark red ascidian Synoicum sp., were evaluated for their inhibitory activities toward Candida albicans isocitrate lyase (ICL). These studies led to the identification of compounds 1, 3, and 4 as potent ICL inhibitors, with IC50 values of 7.62, 17.16, and 10.36 μM, respectively. Growth phenotype of ICL deletion mutants and Northern blot analysis data indicated that compound 1 inhibits the ICL expression in C. albicans under C2 carbon utilizing condition.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Animals
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Benzylidene Compounds / chemistry*
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Benzylidene Compounds / isolation & purification
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Benzylidene Compounds / pharmacology
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Candida albicans / drug effects
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Candida albicans / enzymology*
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Fungal Proteins / antagonists & inhibitors*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Isocitrate Lyase / antagonists & inhibitors*
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Isocitrate Lyase / genetics
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Isocitrate Lyase / metabolism
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Mutation
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Phenols / chemistry*
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Phenols / isolation & purification
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Phenols / pharmacology
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RNA, Messenger / metabolism
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Urochordata / chemistry*
Substances
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Antifungal Agents
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Benzylidene Compounds
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Fungal Proteins
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Phenols
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RNA, Messenger
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Isocitrate Lyase
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4-Butyrolactone